| 摘要 |
NEW MATERIAL:Compound of formula I [R<1> and R<2> are H, halogne, lower alkyl, nitrile, etc.; A is a group of formula II (R<3> and R<4> are H, lower alkyl, aralkyl, or may form a ring of pyrrolidino, piperidino, etc.; together with adjacent N to b1 and b2 are lower alkylene chain] and its salts. EXAMPLE:1-[ 3-( N, N-dimethylamino )propoxy ]-1-( p-fluorophenyl )-4-phenylbutane. USE:Remedies for troubles of the brain and the coronary vessels, which have vasodilating action, spasmolytic action, activating action of brain metabolism and suppressing action of coagulation of blood platelets. PROCESS:The compound of formula I is obtained by reacting a compound of formula III (R<5> and R<6> are H, halogen, etc.; X' is halogen) and a compound of formula IV, and, if necessary, reducing the nitor group, or removing the benzyl or methyl group from the benzyloxy of benzylamino group. |
