发明名称 Improved anti-inflammatory combinations having reduced ulcerogenicity.
摘要 <p>A novel drug combination for more effective treatment of pain, fever, and inflammation with reduced ulcerogenicity comprising either 1-(p-chlorobenzoyl)-5-methoxy-2-methylindo|e-3-acetic acid (indomethacin), and (b) a member selected from phenyl benzoic acid compounds, especially 2-hydroxy-5-(2',4'-difluorophenyl)benzoic acid (diflunisal), wherein the molar ratio of (b) to (a) is from 0.5 to 1.0 to 15.0 to 1.0; or a member selected from (b) and one or more members selected from ibuprofen, ketoprofen, naproxen, diclofenac sodium, tolmetin, flurbiprofen, indoprofen, benozaprofen, piroxicam.</p>
申请公布号 EP0017169(A1) 申请公布日期 1980.10.15
申请号 EP19800101633 申请日期 1980.03.27
申请人 MERCK & CO. INC. 发明人 SHEN, TSUNG-YING
分类号 A61K31/40;A61K;A61K31/105;A61K31/165;A61K31/19;A61K31/235;A61K31/405;A61K31/42;A61K31/44;A61P25/04;A61P29/00;C07C;C07C57/58;C07C59/64;C07C65/05;C07D209/28;(IPC1-7):61K31/62;61K31/615;61K31/61 主分类号 A61K31/40
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