N-Acyl-6-aminopenicillanic acid derivatives, their use as beta-lactamase deactivators, and compositions containing them and beta-lactam antibiotics.

摘要

N-Acyl-6-aminopenicillanic acid sulfones, including methicillin sulfone and the novel compounds quinacillin suifone and cloxacillin sulfone, whose corresponding N-acyl-6-aminopenicillanic acid has a rate constant not more than 100 seconds<-><1>, are of utility as beta -lactamase deactivators and can be administered to animals being treated with a beta -lactam antibiotic. Compositions comprise the sulfones, optionally in admixture with a beta -lactam antibiotic and/or a pharmaceutical carrier.