Phenyl or phenoxy substituted spiro-imidazolidinedione derivatives, pharmaceutical compositions thereof and process for their preparation.

摘要

Novel phenyl or phenoxy substituted spiro-imidazolidinedione derivatives of the formula
wherein X is O, S, SO or SO₂ Y is H, CH₃, CH₃0, Ph, PhO, F, Cl or Br at the 6 or 8 position and Ar is Ph or OPh at the 6 or 8 position, are useful as aldose reductase inhibitors and as therapeutic agents for the treatment of chronic diabetic complications. The derivatives include the phenyl or phenoxy substituted spiro-imidazolidene naphthalene, chroman, thiochroman sulfoxychroman, sulfonochroman dione compounds and the substituted forms thereof. A process for their preparation and pharmaceutical composition are also claimed.