发明名称 PROCESS AND INTERMEDIATES FOR THE PREPARATION OF 2-BENZAZEPINE DERIVATIVES
摘要 <p>1. Process for the manufacture of compounds of the general formula see diagramm : EP0014454,P15,F1 wherein X and Y each signify hydrogen, halogen with an atomic number of at most 35 or trifluoromethyl and n signifies 0 or 1, characterized by treating a compound of the general formula see diagramm : EP0014454,P15,F2 wherein X and Y have the above significance and Z signifies a hydroxyamino, an amino or a protected amino group, under acidic conditions with a mercury (II) salt or in the presence of water with a strong acid, where Z is a protected amino group cleaving off the protecting group and, where a compound of formula I wherein n is 0 is obtained, if desired oxidizing this compound to a compound of formula I wherein n is 1.</p>
申请公布号 EP0014454(A3) 申请公布日期 1980.10.15
申请号 EP19800100547 申请日期 1980.02.04
申请人 F. HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT 发明人 TRYBULSKI, EUGENE J.
分类号 C07C45/63;C07C45/68;C07C45/71;C07C49/784;C07C49/813;C07C49/835;C07C291/04;C07C309/65;C07C309/66;C07D209/48;C07D223/16;(IPC1-7):07D223/16;07C97/10;07D209/48;07C143/68;07C49/835 主分类号 C07C45/63
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