Pharmaceutical heterocyclic compounds, processes for their preparation and compositions containing them.

摘要

The compounds of the formula:
<Chemistry id="chema01" num="0001"><Image id="ia01" he="30" wi="83" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein: R<Sup>1</Sup>, R<Sup>2</Sup>, R<Sup>3</Sup>, R<Sup>4</Sup>, R<Sup>5</Sup> and R', which may be the same or different, each represent hydrogen, hydroxy, alkyl or alkoxy of 1 to 6 carbon atoms, amino, acyl or acylamino of 2 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, halogen, or alkoxy of 1 to 6 carbon atoms substituted by phenyl,
<UnorderedLists id="ula01" listStyle="none"><ListItem>X is a hydrocarbon chain of 1 to 10 carbon atoms optionally substituted by a hydroxy group,</ListItem><ListItem>A is oxygen or is absent,</ListItem><ListItem>Q represents a straight or branched alkylene, alkenylene or alkynylene group of 2 to 6 carbon atoms, and</ListItem><ListItem>D represents carboxy, 5-tetrazolyl or carboxamido-5-tetrazolyl,</ListItem><ListItem>and pharmaceutically acceptable salts, esters and amides thereof,</ListItem><ListItem>are pharmaceutically active, being antagonists of the slow reacting substance of anaphylaxis (SRS-A) or its pathological effects.</ListItem></UnorderedLists>