摘要 |
NEW MATERIAL:The title compound of formula I. USE:An analgesic, antiphlogistic agent, or an intermediate of o-(2,6-dichloroanilino) phenyl acetic acid sodium salt (diclorfenac sodium) of formula V which is an analgesic, antiphlogistic agent. PROCESS:The compound I is prepared by (1) reacting N-(2,6-dichlorophenyl)-anthranylic acid methyl ester with sodium dimsyl, (2) reacting the resulting compound III with iodine, (3) reducing the reaction product, (4) acetylating the resulting 1- [o-2',6'-dichloroanilino)phenyl]-2,2-dimethoxyethanol with acetic anhydride, and (5) treating the product with a base. |