| 摘要 |
<p>PURPOSE:To prepare the title compound, easily, by alkylating a 4-hydroxyindole salt using a novel additon compound of a trialkylsilylisopropylamine and an epihalohydrin as an alkylating agent, and then hydrolyzing the product. CONSTITUTION:A novel trialkylsiloxyhaloalkylamine of formula I (X is Cl or Br) is prepared exclusively and easily, by reacting a trialkylsilylisopropylamine of formula R3Si-NH-CH(CH3)2 (R is methyl or ethyl) with an epihalohydrin by heating. An alkali metal salt of 4-hydroxyindole of formula II is alkylated with the compound I obtained above, and the trialkylsiloxy group of the product is hydrolyzed to obtain the title compound of formula III, which may be further converted to a salt by reacting with corresponding inorganic or organic acid. USE:Remedy for arrythmetic auricular fabrillation and coronary diseases.</p> |
