发明名称 5(10- 9)Abeo-ergoline derivatives, their preparation, and therapeutic compositions containing them.
摘要 <p>Compounds which in form of therapeutic compositions exhibit antihypertensive activity and are of low toxicity. These compounds are of general formula I &lt;CHEM&gt; wherein R1 represents a hydrogen atom, or a carboxy, alkoxycarbonyl, the alkoxy group having 1 to 4 carbon atoms, piperidinocarbonyl, 1-pyrrolidinylcarbonyl, morpholinocarbonyl, carbamoyl or benzylcarbamoyl group, or an alkylcarbamoyl or dialkylcarbamoyl group in which the or each alkyl group has from 1 to 4 carbon atoms, R2 represents a hydrogen or fluorine atom, or a cyano, acetyl or carbamoyl group, R3 represents a hydrogen atom or a methyl group and@@@ represents a single or double bond, with the proviso, that R1 and R2 do not simultaneously represent hydrogen atoms, or pharmaceutically acceptable salts thereof, their preparation and therapeutic compositions containing them. </p>
申请公布号 EP0016411(A2) 申请公布日期 1980.10.01
申请号 EP19800101273 申请日期 1980.03.12
申请人 FARMITALIA CARLO ERBA S.P.A. 发明人 TEMPERILLI, ALDEMIO;MANTEGANI, SERGIO;ARCARI, GIULIANA;CARAVAGGI, ANNA MARIA
分类号 C07D457/02;A61K31/40;A61K31/48;A61P9/12;C07D487/06;(IPC1-7):61K31/40;07D487/06 主分类号 C07D457/02
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