| 摘要 |
PURPOSE:To obtain a blood vessel substitute material excellent in bio- compatibility, by bonding a cell adhesive substance to the inner surface of an artificial blood vessel using extremely fine fibers at least in a part of the inner surface thereof and further bonding a vascular endothelial cell thereto in vitro. CONSTITUTION:In an artificial blood vessel used in a blood substitute material, extremely fine fibers of 0.5 denier or less are used at least in a part of the inner surface of said blood vessel and a cell adhesive substance such as collagen, gelatin or fibrin is applied to said inner surface. Subsequently, an endothelial cell is cultured in vitro to be bonded to the artificial blood vessel. Whereupon, the endothelial starts secretion and a basement membrane component such as collagen is strongly interlaced with the extremely fine fibers and, therefore, the endothelial cell becomes hard to release by blood flow. By this method, the blood substitute material excellent in bio-compatibility and generating no thromboembolism is obtained. |
