摘要 |
The compounds of the formula: <IMAGE> (I) wherein: R1, R2, R3, R4, R5 and R7, which may be the same or different, each represent hydrogen, hydroxy, alkyl or alkoxy of 1 to 6 carbon atoms, amino, acyl or acylamino of 2 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, halogen, or alkoxy of 1 to 6 carbon atoms substituted by phenyl, X is a hydrocarbon chain of 1 to 10 carbon atoms optionally substituted by a hydroxy group, A is oxygen or is absent, Q represents a straight or branched alkylene, alkenylene or alkynylene group of 2 to 6 carbon atoms, and D represents carboxy, 5-tetrazolyl or carboxamido-5-tetrazolyl, and pharmaceutically acceptable salts, esters and amides thereof, are pharmaceutically active, being antagonists of the slow reacting substance of anaphylaxis (SRS-A) or its pathological effects. Pharmaceutical compositions containing the compounds are also described, as well as processes for preparing the compounds. |