| 摘要 |
Phenethylamine compounds useful as anti-phlogistic, anti-arthritic, anti-pyretic and analgesic agents, of formula I <CHEM> wherein R1 is hydrogen, halogen, hydroxy, nitro, (C1-4) alkyl, (C1-4)alkoxy, (C1-4)alkylthio, lower acyloxy or lower acylamino, R2 is (C3-8)cycloalkyl or a phenyl radical, R3 is hydrogen or (C1-4)alkyl, R4 and R5 are the same or different and are hydrogen, (C1-4)alkyl or (C7-11)phenylalkyl, or R4 and R5, together with the nitrogen atom to which they are bound, form a 1-pyrrolidinyl, piperidino or morpholino radical, or R4 and R5 together form a hydrolysable methylene moiety and R6 is hydrogen or a hydrolysable acyl radical, and a process for their production which comprises reducing a compound of formula II <CHEM> in which R1 to R6 are as defined above, and where required appropriately acylating any resulting product having a free hydroxy or amino group and or condensing any resulting compound wherein R4 and R5 are hydrogen with an appropriate aldehyde or ketone. |
