ACIDES PENICILLAMIQUES 6- -SUBSTITUES INHIBITEURS DE -LAC-TAMASE, LEUR PROCEDE DE PRODUCTION ET COMPOSITION PHARMACEUTIQUE LES CONTENANT

摘要

6- beta -Substituted penicillanic acids and derivatives thereof as useful enhancers of the effectiveness of several beta -lactam antibiotics against many beta -lactamase producing bacteria, and 6- beta -substituted penicillanic acid derivatives wherein the carboxy group is protected by a conventional penicillin carboxy protecting group as useful intermediates leading to said synergistic agents. A process for converting 6,6-disubstituted penicillanic acid derivatives to the corresponding 6- beta -substituted penicillanic acid congeners.