Piperidine derivatives, process for their preparation and their use in therapeutical compositions.

摘要

4-Benzyloxy-piperidine <IMAGE> is prepared by (a) condensing 4-hydroxypiperidine with p-nitrobenzoyl chloride in the presence of an acid binding agent, to give a protected piperidine, having the formula: <IMAGE> b) benzylating the protected piperidine with benzyl chloride in the presence of a condensing agent and of an acid binding agent, to give a compound having the formula: <IMAGE> c) releasing the amino group of the piperidine. The resulting base may be converted to a pharmaceutically acceptable salt, and both base and salt are therapeutically useful as antispasmodic agents.