摘要 |
Broad spectrum antibiotics are provided which are compounds of the formula: <IMAGE> wherein -W-R is a residue of a nucleophilic compound and R5 is hydroxyl or protected hydroxyl, or a pharmaceutically acceptable salt or 4-carboxy ester which is the alkoxymethyl, alpha -alkoxyethyl, alpha -alkoxy- alpha -substituted methyl, alkylthiomethyl, acyloxymethyl or alpha -acyloxy- alpha -substituted methyl ester thereof. |