| 摘要 |
Compounds of the formula <IMAGE> I wherein R1 is a straight or branched chain alkynyl group containing from 3 to 9 carbon atoms, inclusive; R2 is hydrogen, (lower)alkyl, halogen or hydroxymethyl; m is 1 or 2, and n is 2 or 3, provided that the sum of m and n is 3 or 4; X and Y each are independently hydrogen, nitro, cyano, -SO2Ar or -COR3, provided that X and Y are not both hydrogen; R3 is (lower)alkyl, Ar, (lower)alkoxy, amino or (lower)alkylamino; and Ar is an optionally substituted phenyl group; and nontoxic pharmaceutically acceptable acid addition salts thereof, are potent anti-ulcer agents. Also disclosed are processes for their preparation and novel intermediates of the formulae <IMAGE> in which R1, X, Y and n are as defined above and R5 is (lower)alkyl, phenylalkyl or phenyl containing 1 or 2 substituents independently selected from nitro, chloro and bromo.
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