| 摘要 |
PURPOSE:To produce blood cholesterol lowering drug by cultivating a monacolin K-producing strain of the microoganism Monascus. CONSTITUTION:Monascus ruber No.1005 (FERM-P4822) strain is cultivated, and the produced physiologically active substance monacolin K is isolated. The substance monacolin K is neutral and colorless crystal. The substance has molecular formula C24H36O5(MW=404). The elemental analysis for C24H36O5:C71.56%; H8.85%; O 19.59%. The substance shows a melting point of 157-159 deg.C and an optical rotation of [alpha]D<25>=+307.6(c=1, in methanol). The substance is soluble in alcohol, acetone, ethyl acetate, chloroform and benzene; and insoluble in hexane and petroleum ether. In chromatographic studies, silica gel thin-layer chromatography employing developer consisting of dichloromethane and acetone in a ratio of dichloromethane to acetone of 4:1 shows a single spot of Rf=0.47. |
