| 摘要 |
A compound of the formula (I): <IMAGE> (I) wherein: X is O or S; Y is -CH2-CH2-, -CH=CH- or -C 3BOND C-; n is 1 to 5; R1 is hydrogen or CO2R1 represents an ester group in which the R1 moiety contains from 1 to 12 carbon atoms; R2 is hydrogen or C1-4 alkyl; R3 is hydroxy or protected hydroxy; R4 is C1-9 alkyl, C3-8 cycloalkyl or C3-8 cycloalkyl-C1-6 alkyl; or R2 and R4 taken with the carbon atom to which they are joined represent a C5-8 cycloalkyl group; and R5 is (CH2)aNR6R7, wherein a is 0 to 3 and R6 and R7 are hydrogen, C1-4 alkyl or phenyl C1-4 alkyl, or R6 and R7 taken with the nitrogen atom to which they are joined represent a 4 to 7 membered heterocyclic ring which may contain as sole further hetero atom one oxygen atom or one optionally C1-4 alkyl substituted nitrogen atom; allyl or propargyl; (CH2)b-CO-(CH2)c-CH3 wherein b+c is 1 to 5 and b is not zero; or S-R8 wherein R8 is C1-6 alkyl, phenyl, or phenyl substituted by a halogen, trifluoromethyl, C1-6 alkyl, C1-6 alkoxy or nitro group; and salts thereof has useful pharmaceutical activity including bronchodilator activity. |
