发明名称 |
Process for the preparation of thiophene derivatives and thiophene derivatives obtained therethrough |
摘要 |
An alpha -(2-thienyl)propionic acid can easily be prepared in a high yield and high selectivity by reacting a 2-(dihaloacetyl)thiophene which is easily obtainable by acetylation and halogenation of a substituted or unsubstutitued thiophene, with a methylmetal compound and then reacting an alkali metal hydroxide with the reaction product. alpha -(2-Thienyl)propionic acids are useful compounds from which, for example, thioprofenic acid can easily be prepared. Thioprofenic acid is known as an anti-inflammatory agent. As reaction intermediates, 1-(2-thienyl)-1-dihalomethylethanols can be obtained. Which are novel and useful compounds.
|
申请公布号 |
US4219659(A) |
申请公布日期 |
1980.08.26 |
申请号 |
US19780910290 |
申请日期 |
1978.05.30 |
申请人 |
SAGAMI CHEMICAL RESEARCH CENTER |
发明人 |
FUJISAWA, TAMOTSU;KUREBAYASHI, AKIRA;SAKAI, KUNIKAZU |
分类号 |
C07D333/16;C07D333/22;C07D333/24;(IPC1-7):C07D333/24;C07D333/28 |
主分类号 |
C07D333/16 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|