| 摘要 |
Cis and trans-3-aryloxy-4- hydroxypyrrolidines and derivatives thereof having the formula: <IMAGE> wherein R<1> represents a hydrogen atom or a loweralkyl, benzyloxycarbonyl or N- loweralkylcarbamoyl group; R<2> represents a hydrogen atom or a loweralkyl, cycloalkyl, phenylalkyl, benzyloxycarbonyl, carbamoyl, N- loweralkylcarbamoyl, N,N- diloweralkylcarbamoyl or parafluorobenzoyl-lower-alkyl group; Ar represents a phenyl, substituted phenyl, 1-naphthyl, 2-naphthyl, 1- indenyl or 2-indenyl group; and pharmaceutically acceptable acid addition and quaternary salts thereof, variously have antidepressant, antihypertensive and antiarrythymic activity in animals and human beings. |
