Chlorobenzyl phenoxy alkanoic compounds.

摘要

Compounds of formula (1)
<Chemistry id="chema01" num="0001"><Image id="ia01" he="29" wi="85" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein R' and R<Sup>2</Sup> are the same or different lower alkyls, R<Sup>3</Sup> is hydrogen, a lower alkyl optionally substituted with a nitrogen-containing basic group or an ion of a pharmaceutically acceptable metal, and R' is hydrogen or nitro; and the acid addition salts of said formula (1) compounds with pharmaceutically acceptable acids when R<Sup>3</Sup> comprises a nitrogen-containing basic group. When R<Sup>4</Sup> is nitro, R<Sup>1</Sup> and/or R<Sup>2</Sup> may also represent hydrogen.

These compounds are useful in the treatment of hypercholesterolemia and hyperlipidemia because of their high effectiveness in reducing the level of cholesterol and lipids in the blood combined with very low general toxicities and substantially reduced hepatomegalitic effects.