| 摘要 |
<p>Disclosed herein are novel D-(threo)-1-aryl-2-acylamido-3-fluoro-1-propanols of the general formula I
<Chemistry id="chema01" num="0001"><Image id="ia01" he="31" wi="57" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>and specified salts thereof, where R represents a specified alkyl, haloalkyl, halodeuteroalkyl, azidomethyl or methylsulfonylmethyl group, X and X' independently represent a hydrogen or halogen atom, a nitro, cyano or a substituted or unsubstituted phenyl group or represent a group R<Sub>1</Sub>(A)<Sub>n</Sub> in which group n is zero or 1, A is oxygen, sulfur, carbonyl, sulfinyl or sulfonyl and R is a specified lower alkyl, amino or lower alkyl amino group and Z is hydrogen or a specified acyl group.</p><p>The novel compounds exhibit antibacterial activity and their use for this purpose is disclosed. Also disclosed are methods for the preparation of the novel compounds as well as certain novel intermediates therefor.</p> |
