发明名称 |
PROCEDEU PENTRU PREPARAREA UNOR 3-CARBAMOILOXIMETILCEFALOSPORINE |
摘要 |
<p>Preparation of the syn isomer or of a mixture of syn isomer and anti isomer, where the content of the syn isomer is at least 90%, of 7-acylaminoceph-3-em-4-carboxylic acids with antibiotic activity and the formula I <IMAGE> in which B is > S or > S->O; R<1> is furyl, thienyl or phenyl; and R<2> is C1-C4-alkyl, C3-C7-cycloalkyl or phenyl, and of their non-toxic salts, including their solvates, and esters by acylation of the corresponding 7-amino compound, where appropriate with intermediate protection of the 4-carboxyl group and/or of the 3-carbamoyloxymethyl group, and subsequent isomerisation of a ceph-2-em compound which is obtained where appropriate to the ceph-3-em compound. The compounds are distinguished by a broad spectrum of action on pathogenic microorganisms, the ability to resist beta -lactamases and good stability in vivo.</p> |
申请公布号 |
RO69607(A) |
申请公布日期 |
1980.08.15 |
申请号 |
RO19740086148 |
申请日期 |
1974.08.19 |
申请人 |
GLAXO LABORATOIRES LTD,GB |
发明人 |
COOK,MARTIN C.,GB;GREGORY,GORDON I.,GB;BRADSHAW,JANICE,GB |
分类号 |
C07D501/32;A61D7/00;A61K;A61K31/43;A61K31/545;A61K31/546;A61P31/04;C07D;C07D501/00;C07D501/04;C07D501/06;C07D501/24;C07D501/26;C07D501/28;C07D501/34;C07D501/60;(IPC1-7):07D501/60 |
主分类号 |
C07D501/32 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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