| 摘要 |
PCT No. PCT/NL80/00005 Sec. 371 Date Oct. 7, 1980 Sec. 102(e) Date Oct. 7, 1980 PCT Filed Feb. 7, 1980 PCT Pub. No. WO80/01685 PCT Pub. Date Aug. 21, 1980.Disclosed are radiolabeled amine compounds, methods for preparing these compounds, diagnostic compositions containing the radiolabeled amine compounds and methods for using these compositions in conducting radiodiagnostic examinations for determining the location and extent of an occurring blood clot in the body of a warm-blooded animal such as a human. The radiolabeled amine compounds of the present invention have the general formula: Y-(CH2)2-X-(CH2)2-NH2 wherein X is selected from the group consisting of oxygen; sulfur; lower alkylene, radioactive selenium; and radioactive tellurium, Y is a hydrocarbyl amino group, and when X is oxygen, sulfur or lower alkylene, Y is a radioactive iodine-substituted hydrocarbyl amino group. Also disclosed are pharmaceutically-acceptable, acid addition salts of the above radiolabeled amine compounds. |
