Novel 1,3-benzodioxaneprostanoic acid derivatives and process for the preparation thereof

摘要

1,3-Benzodioxaneprostanoic acid compound of the formula wherein R1 is hydroxy, alkoxy of 1-10 carbon atoms, methylsulfamido, substituted or unsubstituted aryloxy, or O-CH2-U-V wherein U is a direct bond, carbonyl, or carbonyloxy, and V is phenyl or phenyl substituted, e.g. by one or more of phenyl, phenoxy, alkoxy of 1-2 carbon atoms, and halogen; A is -CH2-CH2 - or trans -CH=CH-; B is -CH2-CH2- or cis- or trans-CH=CH-; Z is hydroxymethylene or carbonyl; X Y, if Z is hydroxymethylene, is or, if Z is carbonyl, is or -CH=CH-; R2 is hydrogen or alkyl of 1-5 carbon atoms; R3 and R4 each are H, F, Cl, Br, I or CF3, CH3 or alkoxy of 1-2 carbon atoms or R3 and R4 in 6-,7-position is methylendioxy; and if R1 is hydroxy, salts thereof with pharmaceutically acceptable bases, are agents for inducing menstruation, interrupting pregnancy, inducing labor and synchronizing the sexual cycle in female mammals.