| 摘要 |
The present invention comprises compounds of the formula <IMAGE> +TR <IMAGE> and the biologically acceptable acid addition salts thereof, wherein R1 represents an alkylene having 2-4 carbon atoms; R2 is selected from the group consisting of amino and quanyl; R3 is selected from the group consisting of nitrophenyl, methylnitrophenyl, dinitrophenyl, naphthyl and nitronaphthyl; X represents halo or lower alkyl having 1-4 carbon atoms; and n is 3 or 4. The compounds of the present invention are analytical reagents useful for measuring proteolytic enzymes such as thrombin and trypsin. The enzymatic hydrolysis of the invention compounds provides a chromogenic amine by which the proteolytic enzyme concentration can be determined spectrophotometrically.
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