(ALPHA)-SUBSTITUTED NEGAMYCIN DERIVATIVES AND SYNTHESES

摘要

.delta.-SUBSTITUTED NEGAMYCIN DERIVATIVES AND SYNTHESES Compounds having the structure were found to be antibacterial agents and were synthesized by a process which comprisesa) reacting diazomethane in the presence of boran trifluoride etherate with a conventional, easily removable ester of amino-protected negamycin to form the intermediate having the formula wherein A is hydrogen and B is a monovalent aminoprotective group or A together with B are a divalent amino-protective group andb) removing from said intermediate the aminoprotective groups A and B and the methyl ester group to form O-methylnegamycin.