| 摘要 |
For the preparation of novel hydroxyamines of the formula <IMAGE> with R<1> to R<4> as in the patent claim, and the acid addition salts of these compounds, a starting compound of the formula <IMAGE> is used. The latter is reacted with a compound of the formula <IMAGE> In this formula, X stands for hydrogen or for a removable group. The resulting isomeric mixtures can be separated into the pure isomers and the resulting racemates into the optical antipodes. The resulting free bases can be converted into a therapeutically acceptable salt thereof or the resulting salts converted into the corresponding free bases. The novel hydroxyamines block cardiac beta -receptors. They are used for the treatment of arrhythmias, of angina pectoris and of hypertension.
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