INDANYL DERIVATIVES,PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM

摘要

Aryloxy-alkylsulphonylaminoindane derivs. and arylthio analogues of formula (I) are new (where Ar is phenyl or pyridyl each opt. substd. by halogen, CF3 or 1-4C alkyl; X is O or S; R1 is 1-4C alkyl opt. substd. by F or Cl; A1 is (CH2)3, CH=CHCH2, CYCH2CH2, CHZCH2CH2, CYCH(SOnR2)CH2 or CHZCH(SOnR2)CH2; Y is O, NOH, 1-4C alkoxyimino, phenylhydrazono or toluene-p-sulphonylhydrazono; Z is OH, 1-6C acyloxy, R1SO3, NH2, 1-6C acylamino, R1SO2NH or CN; n is 0-2; R2 is 1-4C alkyl, or Ph opt. substd. by halogen, 1-4C alkyl, NO2 or COOH; V is H, 1-6C acyl or R1SO2. The -CY- or -CHZ- gp. or -CH2- of CH=CHCH2 are either in the m- or p-posn. to ArX. (I) are herbicides and have analgesic, antipyretic, diuetic, thrombocyte aggregation-inhibiting and antiphlogistic activities; there is a great difference between therapeutic activity and undesirable side effects, esp. ulcerogenic activity, and they hardly inhibit prostaglandin synthesis.