Prostaglandin analogues

摘要

Prostaglandin E1 analogues of the general formula: IV [wherein Y represents ethylene or trans-vinylene, Z represents ethylene or trans-vinylene, R1 represents a hydrogen atom, an alkyl group containing from 1 to 12 carbon atoms, an aralkyl group containing from 7 to 12 carbon atoms, a cycloalkyl group containing from 4 to 7 carbon atoms and unsubstituted or substituted by at least one alkyl group containing from 1 to 6 carbon atoms, a phenyl group unsubstituted or substituted by at least one chlorine atom, trifluoromethyl group, alkyl group containing from 1 to 4 carbon atoms or phenyl group, a -CmH2mCOOR5 group (wherein m represents an integer of from 1 to 12 and R5 represents a hydrogen atom or an alkyl group containing from 1 to 4 carbon atoms), a -CnH2nOR6 group (wherein R6 represents a hydrogen atom or an alkyl group containing from 1 to 4 carbon atoms and n represents an integer of from 2 to 12), or a group (wherein R7 and R8 each represent a hydrogen atom or an alkyl group containing from 1 to 4 carbon atoms and n is as hereinbefore defined), R2 represents a hydrogen atom or a methyl or ethyl group, R3 represents a single bond or an alkylene group containing from 1 to 4 carbon atoms, R4 represents a hydrogen atom, an alkyl group containing from 1 to 8 carbon atoms, a cycloalkyl group containing from 4 to 7 carbon atoms and unsubstituted or substituted by at least one alkyl group containing from 1 to 8 carbon atoms, or represents a phenyl or phenoxy group unsubstituted or substituted by at least one chlorine atom, trifluoromethyl group or alkyl group containing from 1 to 3 carbon atoms, and the wavy line attached to the C-11 and C-15 carbon atoms represents alpha - or beta - configuration or mixtures thereof] and cyclodextrin clathrates thereof, and, when R1 represents a hydrogen atom or a group CmH2mCOOR5 in which R5 represents a hydrogen atom, non-toxic salts thereof and, when R1 represents a group non-toxic acid addition salts thereof, are new compounds and possess characteristic prostaglandin-like properties.