PROCESS FOR PRODUCING NEW 11-OXO-PROSTAGLANDINE DERIVATIVES

摘要

11-Oxoprostaglandin derivatives of the formula wherein R2 is a hydrogen atom or alkyl of 1-5 carbon atoms, R3 is alkyl of 1-5 carbon atoms, alkylaryl, cycloalkyl of 5-6 ring carbon atoms and a total of 5-10 carbon atoms; benzodioxol-2-yl, phenyl, naphthyl or phenyl or naphthyl substituted by phenyl, halogen, alkyl of 1-4 carbon atoms, chloromethyl, fluoromethyl, carboxyl or hydroxy; A is -CH2-CH2-, cis-CH=CH-, or trans-CH=CH-; B is -CH2-CH2- or trans-CH=CH-, D and E collectively are a direct bond or D is alkylene of 1-5 carbon atoms and E is an oxygen or sulfur atom; esters thereof; readily cleavable 9,15 and 9,15 ethers thereof; methanesulfonylamides thereof, and physiologically acceptable salts thereof with bases; possess the activity of the corresponding natural prostaglandins with a surprisingly longer duration of effectiveness, greater selectivity, and better effects, and can be produced, e.g., by oxidation of the corresponding 9-hydroxy prostaglandins.