| 发明名称 |
CYANO ACETIC ACID ANILIDE DERIVATIVES, PROCESS FOR THEIR MANUFACTURE AND COMPOSITIONS CONTAINING THESE COMPOUNDS |
| 摘要 |
<p>A 2-hydroxyethylidene-cyano acetic acid anilide is prepared by heating an acetoacetic acid anilide with an orthoformic acid ester and acetic anhydride, isolating the resulting 2-alkoxymethylene-acetoacetic acid anilide and treating it with hydroxylamine and the isoxazole so obtained with a base, and optionally reacting the resulting alkali metal or ammonium salt with a mineral acid or a strong organic acid. The compounds of the invention have anti-inflammatory and analgetic activity.</p> |
| 申请公布号 |
CA1082202(A) |
申请公布日期 |
1980.07.22 |
| 申请号 |
CA19760254136 |
申请日期 |
1976.06.04 |
| 申请人 |
HOECHST AKTIENGESELLSCHAFT |
发明人 |
ERTEL, HARTMUT;HEUBACH, GUNTHER;WOLF, ERHARD |
| 分类号 |
A61K31/275;A61K31/357;A61K31/36;A61K31/42;A61P25/04;A61P29/00;C07C67/00;C07C233/00;C07C253/00;C07C255/30;C07C255/58;C07C313/00;C07C323/41;C07D261/18;C07D317/58;C07D317/66;G05D16/06;G05D23/12;G09F7/00;H01F7/02;H01J3/02;H01J23/00;H01J23/065;H01J23/087;H01J23/42;H01J25/38;H01J29/38;(IPC1-7):07C121/66;07D317/54 |
主分类号 |
A61K31/275 |
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