| 摘要 |
NEW MATERIAL:A gluco-corticoid sparing factor obtained from the cultured product of indigenous enteric bacteria. Colorless acidic substance; molecular weight, about 400-1,000; composition, a uridine derivative containing uracil, pentose, hexose and phosphoric acid unstable to acid; solubility, easily soluble in water, dilute acid, and dilute alkali, sparingly soluble in organic solvents. USE:Agent for improving the activity of gluco-corticoid. Promotes the induction of hepatic enzyme by gluco-corticoid (e.g. tyrosine amino-group transferase). PROCESS:Indigenous enteric bacteria such as Proteus, Lactobacillus, Streptococcus, etc. are cultured, and the bacterial cells are separated from the medium by centrifugal separation, etc. The cells are disintegrated by ultrasonic radiation, the effective component in the cell is extracted, proteins are removed from the extract, and the objective compound is separated by adsorbing with activated charcoal. The adsorbed substance is eluted with alkali-acetone mixture, etc., neutralized, and purified to obtain the objective gluco-corticoid sparing factor. |
