| 发明名称 |
PROCEDEU PENTRU PREPARAREA UNOR 7-ALCOXI-3-CLORMETILCEFEMI |
| 摘要 |
<p>7-Alkoxy-3-chloromethyl-3-cephems are provided by reacting a 3-methylenecepham with an alkali metal salt of a lower primary alcohol in the presence of tert-butyl hypochlorite at a temperature ranging from about -80 DEG to about 0 DEG C. The 3-chloromethylcephems provided by this invention are useful intermediates for the preparation of known cephalosporin antibiotics.</p> |
| 申请公布号 |
RO70052(A) |
申请公布日期 |
1980.07.15 |
| 申请号 |
RO19770089740 |
申请日期 |
1977.03.21 |
| 申请人 |
ELI LILLY AND CO,US |
发明人 |
KOPPEL,GARY A.,US |
| 分类号 |
A61K;A61K31/545;A61K31/546;C07C;C07D;C07D501/00;C07D501/04;C07D501/18;C07D501/24;C07D501/28;C07D501/32;C07D501/34;C07D501/57;C07D501/60;(IPC1-7):07D501/60 |
主分类号 |
A61K |
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