URACIL DERIVATIVES AND PRODUCTION THEREOF

摘要

of the disclosure New derivatives of the formula: (wherein X is O or NH; R1 is -OH or -SH which may optionally be etherified or esterified, or -NH2 which may optionally be substituted; R2 and R3, respectively, mean H, lower alkyl or ; and Y is an esterified or amidated carboxyl group, or CN). These derivatives are produced, by fluorination of corresponding 1,2,3,4tetrahydro-2,4-dioxopyrimidine compounds and can be converted into 5-fluorouracil derivatives under hydrolytic conditions The new derivatives are able to prolong the lives of animals having carcinomas or have antiviral activity.