| 摘要 |
Inhibitors of angiotensin converting enzyme which are physiologically acceptable salts of compounds which have the formula: <IMAGE> wherein R is hydrogen, formyl, acetyl, propanoyl, butanoyl, phenylacetyl, phenylpropanoyl, benzoyl, cyclopentanecarbonyl, tert-butyloxycarbonyl, cyclopentanecarbonyl-L-lysyl, pyro-L-glutamyl-L-lysyl, L-lysyl, L-arginyl or pyro-L-glutamyl; A is phenylalanyl, glycyl, alanyl, tryptophyl, tyrosyl, isoleucyl, leucyl, histidyl, or valyl, the alpha -amino group thereof being in amide linkage with R; R1 is hydrogen or methyl; R2 is L-proline, L-3,4-dehydroproline, D,L-3,4-dehydroproline, L-3-hydroxyproline, L-4-hydroxyproline, L-thiazolidine-4-carboxylic acid, or L-5-oxo-proline, the imino group thereof being in imide linkage with the adjacent <IMAGE> and, n is 0 or 1, such that when n is O, R1 is methyl are disclosed as useful anti-hypertensive agents. |
