| 摘要 |
<p>The somatostatin-analogous peptides according to the invention of the general formula <IMAGE> in which Bmp represents the desaminocysteine radical X represents Asn or His, trp represents D-Trp that may be substituted in the benzene ring by a halogen atom, and Y represents the radical of a secondary alpha -amino acid having a maximum of 8 carbon atoms and the corresponding peptide amides and also acid addition salts and complexes thereof are distinguished by strong insulin-antagonistic and glucagon-antagonistic effects and are therefore therapeutically acceptable, preferably in the form of pharmaceutical preparations, in similar indications to those of somatostatin, especially also as antidiabetics. The compounds are manufactured by conventional processes of peptide synthesis, especially by liberation from corresponding protected intermediates and by the formation of the cystine disulphide bridge by means of oxidation.</p> |
