PEPTIDYL DERIVATIVES FOR PHOSPHONIC ACIDS,THEIR MANUFACTURE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

There is provided peptide derivatives of the general formula wherein R1, R2 and R3 each represent the characterizing group of an alpha -amino acid of the type normally found in proteins; R4 represents a hydroxy or methyl group; n stands for zero, 1, 2 or 3; the configuration at the carbon atoms designated as (a), (b) and (c) is L (when R1 or R2 NOTEQUAL H); and the configuration at the carbon atom designated as (d) is (R) (when R3 NOTEQUAL H) and pharmaceutically acceptable salts thereof.