摘要 |
Cephalosporin C derivatives(I, M =H, ankali metal; X = halogen)were prepd. by reaction of cephalosporin C(II) with phthalic anhydride(III). 16.2 g Tetrabromophthalic anhydride powder contg. acetone 2N NaOH were mixed with a culture broth condensate contg. 1.5 (II) and stirred for 1 hr at room temp. and adjusted pH 9.0-8.5 to give 14.2 g(I) (85%). IR, NMR and UV charts of I were presented.
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