DERIVATIVES OF 3-SUBSTITUTED AMINO-TOLYPOMYCINONE AND 1,4-DIHYDRO TOLYPOMYCINONE AND PHARMACEUTICAL COMPOSITIONS THEREOF

摘要

Cpds. of formula (I) are new: (where R is opt. substd aliphatic hydrocarbyl, the C chains opt. being interrupted by O,S and/or N atoms(s); Q is -CH=C(CH3)-; -CH2CH(CH3)- or -CH2- (CH3)-; the gps. are pref. both the same). (I) are antibiotics and are more stable in acid medium than Tolypomycin Y and better activity than tolypomycinone. They are bactericides with activity against Gram positive and -negative bacteria and are useful for treating infections in animals and man. Their stability towards acids makes them suitable for oral administration. (I) are useful in treatment of pneumonia, digestive tract infections and various types of abscess.