| 摘要 |
<p>1. Device for studying cellular migration, intended in particular for studying leucocytary and monocytary migration, of the type having at least one migration chamber (12) which comprises a base provided with a flat sided opening (14), a first duct (16) opening into each chamber (12) in the region of its top and a second duct (18) opening also into each chamber (12) on the lateral side wall thereof substantially at mid height between its top and its base, the said ducts (16, 18) being connected by an external connection circuit incorporating a circulation pump characterised in that it contains in addition a plurality of ducts (20) opening into each chamber (12) in the region close to its base and an external chamber (22) enclosing the assembly of the migration chamber or chambers (12) except at the base opening (14), the external chambers (22) and the migration chamber(s) (12) being connected in a pressure-tight manner, in particular at the level of their base, and delimiting between themselves a space (24) intended to be traversed by a temperature regulating fluid circulating between an inlet duct (26) and an outlet duct (28) of the external chamber (22), in that the assembly of ducts (20) opening in the region of the base of each migration chamber (12) is connected to the second duct (18) opening at mid height of each chamber (12) in a manner to ensure a permanent agitation by liquid flow of the reactive liquid medium contained in each migration chamber (12) and in that the edge of the opening (14) arranged in the base of each migration chamber (12) is provided in a manner to permit either the placing of the device on the skin with the interposition of a micro-porous filter (30) of a porosity in the order of 3 to 5 mu m, or possibly positioning of the device directly on a mucous membrane.</p> |
