Prostaglandin analogues

摘要

The invention relates to prostaglandin analogues of the general formula: <IMAGE> (wherein A represents a grouping of the formula: <IMAGE> B represents an alkylene group containing from 1 to 7 carbon atoms or a group <IMAGE> (wherein the group -(CH2)n-may be attached to the ortho, meta or para position of the phenyl ring and m and n, which may be the same or different, each represent an integer from 1 to 5 inclusive, the sum of the integers represented by m and n being from 2 to 6 inclusive), X represents ethylene or cis-vinylene, Y represents ethylene or trans-vinylene, W represents ethylene or trans-vinylene, Z represents a halogen atom, and R1 represents a hydrogen atom or an alkyl group containing from 1 to 12 carbon atoms) and cyclodextrin clathrates of such acids and esters and, when R1 represents a hydrogen atom, non-toxic salts thereof, which possess characteristic prostaglandin-like properties.