PROCEDEU PENTRU PREPARAREA UNOR DERIVATI AI 5-PIRAZOLONEI

摘要

1-Substituted pyrazole-5-ones of the formula AND PHARMACEUTICALLY ACCEPTABLE, NONTOXIC SALTS THEREOF, WHEREIN R is hydrogen or amino; R1 is hydrogen, alkyl, alkenyl, unsubstituted or substituted aryl or unsubstituted or substituted aralky; X is A. ETHYLENE, ETHYLENE WHEREIN 1 HYDROGEN ATOM ON ONE OF THE CARBON ATOMS IS SUBSTITUTED BY ALKYL OF 1 TO 4 CARBON ATOMS, ETHYLENE WHEREIN 1 HYDROGEN ATOM ON EACH OF THE TWO CARBON ATOMS IS SUBSTITUTED BY ALKYL OF 1 TO 4 CARBON ATOMS OR SAID ETHYLENE WHICH IS LINKED TO R2 via an oxygen or sulphur atom; B. PROPENYL, PROPENYL WHEREIN 1 HYDROGEN ATOM ON ONE, TWO OR THREE OF THE CARBON ATOMS IS SUBSTITUTED BY ALKYL OF 1 TO 4 CARBON ATOMS, SAID PROPENYL BEING LINKED TO THE N1 atom of the pyrazol ring via its methylene moiety; or C. METHYLENE; PROVIDED THAT WHEN X is methylene, R1 is not hydrogen if R is amino; R2 is aryl unsubstituted or substituted by: