发明名称 |
Nuclear substituted 2-hydroxymethane-sulfamic acids and pharmaceutical compositions. |
摘要 |
<p>Nuclear substituted 2-hydroxyphenylmethane-sulfamic acids and their pharmaceutically acceptable salts wherein the phenyl nucleus is substituted with 2 to 4 nuclear substituents and which are useful saluretic-diuretics and anti-inflammatories are disclosed. The products may be prepared by reacting nuclear substituted salicylaldehydes with ammonium sulfamate to generate intermediate imines which are reduced to afford the compounds of this invention.</p> |
申请公布号 |
EP0011654(A1) |
申请公布日期 |
1980.06.11 |
申请号 |
EP19780101444 |
申请日期 |
1978.11.23 |
申请人 |
MERCK & CO., INC. |
发明人 |
SMITH, ROBERT LAWRENCE;STOKKER, GERALD EDWARD;CRAGOE, EDWARD JETHRO, JR. |
分类号 |
A61K31/19;A61K31/18;A61P7/10;A61P9/12;A61P29/00;C07C45/56;C07C67/00;C07C301/00;C07C307/02;C07C313/00;C07C323/49;(IPC1-7):07C143/86;61K31/185 |
主分类号 |
A61K31/19 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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