| 摘要 |
4-Hydroxy-2H-naphtho[2,1-e -1,2-thiazine-3-carboxamide-1,1-dioxides(I, R1 = methyl, ethyl; Ar = phenyl, 3-chlorophenyl, 3-bromophenyl, 2-methoxyphenyl, 2-pyridyl, 2-pyrazinyl, 2-thiazolyl, 5-methyl-3-isoxazolyl), useful as antiphlogistic, blood platelet aggregation inhibitor, were prepd. by hydrolyzing enaminic carboxamide(IIa, R4 and R5 are C1-3 alkyl; R1 and Ar are given) obtained by reaction of enaminic chloride(II, Hal = halogen) and aromatic amine(III) at -40-80≦̸C in the presence of inert organic solvent.
|
