ACTIVE DERIVATIVES OF METHYLAMINE, THERAPEUTIC COMPOSITIONS CONTAINING THE SAME AND PROCESSES FOR PREPARING SAID DERIVATIVES AND COMPOSITIONS

摘要

n-Butylamine derivatives having the general formula: I and the pharmaceutically acceptable acid addition salts thereof wherein R4 represents hydrogen, propargyl or 2-hydroxyethyl, R5 represents methyl, propargyl, 2-hydroxyethyl, 3-hydroxy-n-propyl or R4 and R5, when they are taken together, represent methylene, ethylene, trimethylene, ethylidene or -CH2-CH2-O-CH2-CH2- and R2 is such that :- when R4 repsesents hydrogen and R5 represents methyl, R2 represents n-propyl, isopropyl, isobutyl or allyl- when R4 represents hydrogen and R5 represents propargyl, 2-hydroxyethyl or 3-hydroxy-n-propyl or when R4 and R5 are identical and each represent propargyl or 2-hydroxyethyl or when R4 and R5 are taken together and represent methylene, ethylene, trimethylene, ethylidene or -CH2-CH2-O-CH2-CH2-, then R2 represents n-propyl. These derivatives present central noradrenergic and central dopaminergic properties which make them useful in treating Parkinson's desease as well as for correcting extrapyramidal disturbances provoked by neuroleptics.