ADDITION COMPOUND OF DIPEPTIDE ESTER WITH AMINO ACID ESTER

摘要

NEW MATERIAL:A compound I (X is benzyloxycarbonyl which may have nucleus- substitution group; Y is side chain group of amino acid; R and R' are lower alkyl, and when Y is benyl, R is different from R'). EXAMPLE:The addition compound of N-benzyloxycarbonyl-L-aspartyl-L-phenylalanine ethyl ester and phenylalanine methyl ester. USE:Intermediates of optically active amino acid esters useful as raw material for synthetic sweetening, etc. and those of optically active amino acides useful as nutriments for animals and as raw materials for antibiotics, etc. The optical resolution of a racemic amino acid ester can be easily carried out by using the compound of the invention as an intermediate. PROCESS:An optically active compound II (e.g. LL-form) is reacted with a recemic modification III in a solvent to give preferentially or predominantly the optically active addition compound IV comprising the optically active form II and its antipode III (e.g. D-form).