发明名称 |
PROCESS FOR THE PREPARATION OF THE NOVEL 2-HALOGENATED 8-AND 1,8-SUBSTITUTED ERGOLENE DERIVATIVES |
摘要 |
<p>The invention relates to novel 2-halogenated 8- and 1,8-substituted ergolene derivatives of the formula (I) and the acid addition salts thereof, pharmaceutical compositions containing them and a process for their preparation. In the formula (I) <IMAGE> (I) wherein X stands for a halogen; R stands for a C1-4 alkyl group and R'' means a hydroxyl group; or R stands for an acyl or substituted acyl group and R'' represents a halogen or an -OR' group, wherein R' stands for an acyl or substituted acyl group; or R stands for hydrogen and R'' means a halogen or an -OR' group, wherein R' stands for an acyl or substituted acyl group; and the dotted line means a double bond between the 8-9 or 9-10 positions. The compounds of the formula (I) possess an antipsychotic and antihypoxic action and a negligable extrapyramidal side-effect.</p> |
申请公布号 |
IN165245(B) |
申请公布日期 |
1989.09.09 |
申请号 |
IN1987CA32619 |
申请日期 |
1987.04.24 |
申请人 |
RICHTER GEDEON VEGYESZETI GYAR RT. |
发明人 |
KEVE TIBOR;MEGYERI GABOR;STEFKO BELA;JUN LAJOS KOVACS;ZIGER ANNA KASSAI NEE;KISS BELA;LASZLOVSZKY ISTVAN;LAPIS ERZSEBET;PALOSI EVA;GROO DORA;SZPORNY LASZLO |
分类号 |
A61K31/48;A61P9/00;A61P25/18;C07D457/02;(IPC1-7):A61K31/395;C07D227/00 |
主分类号 |
A61K31/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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