PROCESS FOR PREPARING THE NEW BU-2231 GLYCOPEPTIDE ANTIBIOTIC COMPLEX, THE SINGLE COMPONENTS AND THEIR DERIVATIVES

摘要

New complex glycopeptide antibiotics Bu-2231A (I) and Bu-2231b (II) are obtd. by culturing Streptoalloteichus hindustanus ATCC 31158 or its mutants, and sepd. the product (Bu-2231) into (I) AND (II) in the form of Cu complexes. (I) and (II), in both the Cu-complex and Cu-free form, are broad-spectrum antibacterials with higher activity than bleomycin NIHJ and phleomycin 616 against a wide range of Gram-positive, Gram-negative and acid-resistant microorganisms. They are also antifungal agents (for medical or agricultural use), and inhibit the growth of Walker 256 carcinosarcoma and Lewis carcinoma in rats.