Synthetic peptides, their preparation, pharmaceutical formulations containing them and intermediates for their preparation.

摘要

The tetradecapeptides of the formula
wherein X is H-Ala-D-Ala, H-D-Ala-Gly, or H-D-Val-Gly; and X¹ is Ala-Leu, Ala-Phe, Ala-D-Phe, D-Ala-Phe, or D-Ala-Cha; or the non-toxic, pharmaceutically acceptable acid addition salts thereof; inhibit secretion of growth hormone, while not materially inhibiting the secretion of insulin or glucagon. The compounds are prepared by oxidation of intermediates of the formula